Santos was born in New York, New York of Portuguese and Irish heritage. He attended Hunter College in Manhattan, New York to originally pursue a career in physics and medicine.
He has also studied with many acting coaches like Penny Tempalton and Janet Alhanti. He is best remembered as the character Dante Belasco in Jeepers Creepers 2 and also had starring roles in the television series The Help and Grosse Pointe. He also made guest appearances on CSI:NY. Santos was formerly a model for Ford Modeling Agency.
He has modeled clothing for top fashion names such as Versace, Armani, Valentino, and Abercrombie & Fitch.
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